Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1
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چکیده
منابع مشابه
Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1
BACKGROUND Obesity-induced hepatic lipid accumulation causes lipotoxicity, mitochondrial dysfunction, oxidative stress, and insulin resistance, and is implicated in non-alcoholic hepatic pathologies such as steatohepatitis and fibrosis. Heme oxygenase-1 (HO-1), an important antioxidant enzyme catalyzing the rate-limiting step in heme degradation, protects against oxidative stress, inflammation,...
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BACKGROUND/OBJECTIVES Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes and thus is implicated in protection against inflammatory diseases. Here, we show that the flavonoid...
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BACKGROUND Hyperglycemia is one of the most dangerous factors causing diabetic nephropathy. Salidroside is considered to have the effects of reducing oxidative stress damage and improving cell viability. This study was performed to investigate whether and how salidroside reduces high-glucose (HG)-induced apoptosis in mouse podocytes. MATERIAL AND METHODS We examined whether salidroside could de...
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Adipose macrophages with the anti-inflammatory M2 phenotype protect against obesity-induced inflammation and insulin resistance. Heme oxygenase-1 (HO-1), which elicits antioxidant and anti-inflammatory activity, modulates macrophage phenotypes and thus is implicated in various inflammatory diseases. Here, we demonstrate that the HO-1 inducer, hemin, protects against obesity-induced adipose infl...
متن کاملHeme Proteins, Heme Oxygenase-1 and Oxidative Stress
Heme is ferrous protoporphyrin-IX that is the prosthetic group of hemoproteins, such as hemoglobin, myoglobin and cytochromes that are of vital importance. In contrast, “free heme”, a protein-unbound heme, that is either just synthesized but yet not incorporated into hemoproteins, or that is released from hemoprotein under oxidative conditions, is highly toxic, since it catalyzes the production...
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ژورنال
عنوان ژورنال: Nutrition & Metabolism
سال: 2015
ISSN: 1743-7075
DOI: 10.1186/s12986-015-0030-5